In Supergirl 19, she returns to her classic costume, complete with the opening on her chest, after her then-current costume is badly damaged.
Lip does not show her any reaction, and simply tells her that he is with Mandy now.
While on her way to the streets of Manhattan to assist her teammates, Karen hears Ma Hunkel screaming.
This version appears to be Kryptonian as she is shown to be susceptible to kryptonite and is slain by that world's version of Batman.
In common with Supergirl's origin story, she is the daughter of Superman's and and a native of the planet.
Karen is devastated at losing the one other person other than her mother that she thought she could count on.
The baby is of Asian-American descent, and has Down Syndrome.
She starts to use people, lie, and take advantage of them to get what she wants.